Ozone Oil: Uses, Benefits, and How to Get Started

Over the past few decades there has been a drastic increase in skin infections. The standard healthcare system hasn't done a good job of eliminating these skin issues, which range from bacteria to diabetes and everything in between. Although these are not usually deadly, they still pose an epidemic problem because the standard care is expensive and not very effective.

Enter ozone oil, the use of which is said to "appear providential" because of how it works with all of these skin issues. As one of the most versatile applications of ozone therapy, ozonated oils offer a stable, easy-to-use option for home applications.

This guide covers everything you need to know about ozone oil -what it is, how it works, what it treats, and how to use it effectively.

DE UN VISTAZO:

• Los programas sanitarios estándar hacen poco por ayudar a los 1.500 millones de personas afectadas por infecciones de la piel y las mucosas 
• El aceite de ozono puede ser eficaz para una multitud de problemas de la piel, ya que es un fuerte antiséptico que estimula los procesos de curación del cuerpo.
• No todos los aceites de ozono son iguales 

En las últimas décadas se ha producido un aumento drástico de las infecciones cutáneas. El sistema sanitario estándar no ha hecho un buen trabajo a la hora de eliminar estos problemas cutáneos, que van desde las bacterias a la diabetes, pasando por todo lo demás. 

Aunque no suelen ser mortales, siguen planteando un problema epidémico porque los cuidados estándar son caros y poco eficaces.

El aceite de ozono, cuyo uso se considera "providencial" por su efecto sobre todos estos problemas cutáneos.

¿Qué es el aceite de oliva ozonizado?

Ozonated olive oil is created when ozone-oxygen gas is infused into oil. It's a lengthy process that ozonates the oil by creating peroxides. These peroxides are what give the oil its therapeutic properties.

Unlike pure ozone gas, which dissipates quickly, ozonated oil stores these beneficial compounds in a stable form. The result is a thick, gel-like substance with a distinctive smell that can be applied topically or used internally.

Ozonated olive oil is commonly used for acne, wrinkles, eczema, psoriasis, skin infections, athlete's foot, and more.

As Dr. Velio Bocci, who devoted over 30 years to ozone research, documented:

"The ozonated oil is now used topically for the treatment of war wounds, anaerobic infections, herpetic infections (HHV I and II), trophic ulcers and burns, cellulitis, abscesses, anal fissures, decubitus ulcers (bed sores), fistulae, fungal diseases, furunculosis, gingivitis and vulvovaginitis."

If you're new to ozone therapy, download our free guide to getting started for comprehensive protocols and practical guidance.

¿Para qué se utiliza el aceite de ozono?

Antes de entrar en cómo funciona el aceite de ozono, he aquí una lista rápida de lo que suele tratar:

• Acné
• Rosácea
• Arrugas 
• SARM
• Heridas infectadas
• Heridas no curativas
• Úlceras
• Infecciones orales
• Encías retraídas
• Eczema
• Psoriasis
• Pie de atleta
• Y mucho más

¿Cómo funciona el aceite de oliva ozonizado para tantos problemas (más de 50)? 

Para ser una modalidad tan extraordinaria que puede tratar tantas cosas, el funcionamiento del aceite de ozono es sorprendentemente sencillo. Sólo hace dos cosas:

1. Kills Pathogens

Infections, acne, and many issues on the skin are caused partly by bad bacteria. Ozone oil kills bad bacteria and restores the skin. It stimulates the natural production of hydrogen peroxide in the tissue. Your body makes this already -ozone oil just upregulates how much is produced.

Research published in the Journal of Ozone Therapy shows that ozonated oils eliminate pathogens without the tissue damage caused by chemical antiseptics like bleach or alcohol.

2. Regenerates Collagen and Speeds Healing

As you age, your collagen is damaged and reduced -which makes your skin more wrinkly and older-looking. Ozone oil stimulates growth factors and the regeneration of collagen.

La piel aprende de forma natural a repararse y fortalecerse. El aceite de ozono simplemente estimula este proceso.

Dr. Bocci predicted:

"Me gustaría predecir que la aplicación de aceite ozonizado, un remedio sencillo y barato, llegará a ser mucho más útil que las costosas cremas farmacéuticas y anunciará una revolución médica para el tratamiento tópico..."

Nuestro cuerpo funciona con oxígeno. Y una de las cosas que puede hacer el ozono es difundir lentamente oxígeno a la zona afectada.

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Paciente con acné antes y después del uso de aceite de ozono

Paciente con acné antes y después del uso de aceite de ozono

Paciente con eczema antes y después del uso de aceite de ozono

What People Are Saying

These are from publicly available reviews online:

"I have tried many other creams ointments and pills to help an inflamed area of my body…skin- topical, possibly histamine related. Thanks to Simply O's Sunflower oil that layer of inflammation has subsided." - Kimberly O.

"Helped with psoriasis keeping it under control. No crazy medications or things in it that cause adverse reactions like so many psoriasis specific meds." - Jason R.

"My skin is well hydrated and finally happy! I am prone to redness, itching and reactions -all of which have completely resolved since using." - Janet E.

"My daughter is prone to dry skin and has broken out in patchy eczema. Keeps her skin intact and hydrated. Haven't had an episode since." - Vanessa G.

"I had nail fungus under 7 of my toe nails and it was steadily getting worse - nothing would stop it. The ozonated oil cleared up all but 3 toes over a 12 month period. Applied twice a day. It's hard to tell I ever had the fungus." - Warwick P.

"I had a small bump on the skin on the bridge of my nose. After applying the O3 oil it steadily got smaller and disappeared in about 10 days." - Paul I.

The Science Behind Ozone Oil

For all you science nerds, here are studies demonstrating how ozone oil works:

Healing pathway - what it upregulates:

"Assays showed that ozone oil up-regulated collagen I, α-SMA, and TGF-β1 mRNA and protein levels in fibroblasts"

Wound healing with oil control - shows effect of the ozonated oil vs. standard oil:

"Basándose en los resultados del cierre de la herida entre el grupo del ozono y el grupo del aceite en los días 0, 3, 5, 7 y 11, el grupo del ozono mostró un tamaño de la herida y un área residual de la herida significativamente menores que el grupo del aceite"

Antimicrobial efficacy - demonstrates antimicrobial effect:

"Ozonated oils have demonstrated activity and can be proposed for use in the prevention and treatment of chronic local infections, in appropriate formulations and in controlled cases, as an alternative to topical antimicrobial agents."

A clinical trial comparing OLEOZON (ozonated sunflower oil) to conventional treatment for dental wounds found that 92% of patients healed with ozonated oil compared to 78% with the standard treatment. Patients using ozonated oil also required fewer follow-up visits.

For more on the research behind ozone therapy, explore our guide on comparing IV ozone therapy options.

Want to understand the full scope of ozone therapy? Get our free comprehensive guide.

How to Use Ozone Oil

Getting results from ozonated olive oil requires understanding proper application methods.

For Skin Conditions and Wounds

1. Clean the affected area if possible
2. Apply a thin layer of ozonated oil -a little goes a long way
3. Allow it to absorb (no need to cover unless protection is needed)
4. Repeat up to 2-3 times daily (if severe issue)
5. Continue use until the condition resolves, plus a few extra days

The oil-like texture warms and spreads easily with body heat. For best results, be patient -some conditions like nail fungus require weeks or months of consistent application.

For Daily Skincare

Many people incorporate ozone oil into their nightly routine. Applied before bed, it works while you sleep to:

• Hydrate deeply without clogging pores
• Support collagen production
• Address minor blemishes and irritation

"I have been using for several years now and find more and more benefits. It really helps keep skin clear -body and facial." - Kimberly O.

Storage Tips

• Keep refrigerated for maximum shelf life (6-12 months)
• At room temperature, potency decreases faster
• Close container tightly after use
• Avoid heat and direct sunlight

Ozone Oil for Dental Health

One of the most effective applications of ozone oil is for oral health. Oil pulling -swishing oil in the mouth -takes on new dimensions when using ozonated oil.

The mouth contains miles of microscopic tubules in the teeth. Regular oil pulling with ozonated oil helps:

• Reduce harmful bacterial populations
• Support gum tissue health
• Reach areas that brushing and flossing miss

Dr. Stuart Nunnally, a biological dentist with decades of experience, explains:

"We use ozone in all kinds of infections. Many times we can use ozone without using antibiotics, because we can use it in the area of wounds and in the areas where we anticipate and want to have robust healing."

On oil pulling specifically, Dr. Nunnally notes: "We encourage oil pulling. There's great data, most of it's anecdotal, but we know it doesn't do any harm."

"I was having issues with bleeding gums that wouldn't heal and would get irritated after flossing. After about 10 days of oil pulling twice a day, my gums finally healed!" - Donna K.

How to Oil Pull

1. Use 1-2 teaspoons of ozonated oil
2. Swish gently for 10-20 minutes (start with 5 if new to oil pulling)
3. Spit into trash (not sink -it can clog pipes)
4. Rinse mouth with water
5. Follow with normal brushing

For best results, oil pull first thing in the morning before eating or drinking.

For more on ozone applications in oral health, see our guide on ozone therapy for ear, nose, and throat conditions.

What Applications Are Ozone Oils Used In?

Ozone oil is a multi-purpose product that can be used for a wide range of issues:

Cosmetic purposes - Acne, wrinkles, rosacea, sores, and blemishes

Medical purposes - MRSA, ulcers, non-healing wounds, burns, rashes

Tooth and gum purposes - Receding gums, cavitations, infections, sores, post-surgery healing

Gut health - Consuming organic ozone oil capsules is helpful for parasites, stomach ulcers, and gut health

Vaginal and rectal applications - Ozone oil suppositories can assist with infections without harming the biome. For more on this delivery method, see our guide on rectal ozone therapy.

How to Choose Quality Ozone Oil

Not all ozonated oils are created equal. Understanding quality markers helps you choose effectively.

What "Fully Ozonated" Means

The ozonation process continues until the oil reaches a saturation point. Key indicators of quality:

• Peroxide value (PV) - Measures the concentration of ozonides. Higher values mean more potent oil.
• Consistency - Fully ozonated olive oil has a thick, gel-like texture, not liquid
• Color - Changes from golden to lighter, more opaque appearance
• Smell - Properly ozonated oil has a distinctive ozone odor

What to Look For

• Base oil quality - Organic, extra virgin olive oil produces the best results
• Ozonation method - Medical-grade ozone generators ensure consistency
• Concentration options - Some products offer different potency levels for different uses
• Storage guidance - Quality products include proper storage instructions

"I love that there are multiple options for strength so I can choose which one based on what I'm using it for." - Kayte S.

If you're interested in making your own ozonated oil, you'll need an ozone therapy machine for home use. The process requires bubbling ozone through oil for several days to achieve full ozonation.

Side Effects and Safety

One of the remarkable aspects of ozonated olive oil is its safety profile. Studies on ozonated oils in skin diseases published in peer-reviewed journals document consistent use without significant adverse effects.

Known Considerations

• Smell - Fully ozonated oil has a distinctive ozone odor that some find strong
• Texture - The oil-like consistency differs from regular oils, often slightly thicker
• Skin sensitivity - Those with very sensitive skin should patch test first

Who Should Consult a Doctor First

While generally safe, speak with a healthcare provider before using ozonated oil if you:

• Are pregnant or nursing
• Have a known allergy to olive oil
• Have open wounds near the eyes
• Are treating a serious medical condition

There are no known negative effects of using ozone oil on the skin or mouth.

Frequently Asked Questions

How long does ozonated olive oil last?

When refrigerated, quality ozonated olive oil maintains potency for 6-12 months. At room temperature, it degrades faster. Always check manufacturer guidelines and store in a cool, dark place with the container tightly closed.

Can I make my own ozonated olive oil?

Yes, with an ozone therapy machine for home use. The process requires bubbling ozone through oil for several days to achieve full ozonation. Most people find it more practical to purchase pre-ozonated oil.

Is ozone oil safe for sensitive skin?

Most people with sensitive skin tolerate ozonated olive oil well. The oil is generally less irritating than many conventional treatments. However, it's wise to patch test on a small area first before applying to larger areas.

How is ozone oil different from regular olive oil?

The ozonation process transforms fatty acids in olive oil into ozonides - compounds with antimicrobial and tissue-regenerating properties not present in regular olive oil. The texture also changes from liquid to a thick, gel-like consistency.

How quickly will I see results?

Results vary based on what you're treating. Some users report improvements within days for minor issues like small skin bumps. Chronic conditions like nail fungus may require months of consistent, twice-daily application.

The Bottom Line

Ozone oil represents one of the most accessible and versatile applications of ozone therapy. By combining antimicrobial power with tissue regeneration in a stable, easy-to-use form, it addresses issues that conventional treatments often struggle with.

The science supports what users experience: this isn't just another natural remedy trend. The mechanisms are documented, the safety profile is excellent, and the results speak for themselves.

Whether you're dealing with a stubborn skin condition, looking to improve your dental health routine, or simply want to add a powerful tool to your natural health approach, ozonated olive oil deserves serious consideration.

Ready to learn more?

‍Download our free Definitive Guide to Getting Started with Ozone Therapy for comprehensive protocols and practical guidance.

Types of Ozonated Products

Beyond topical ozone oil, several related products serve specific purposes:

• ozone oil capsules - For internal use and gut health
• ozone oil suppositories - For rectal or vaginal applications
• oil pulling with ozonated oil - For oral and dental health
• ozone oil for joint pain - Targeted pain relief
• ozonated glycerin - Water-soluble alternative
• ozone water - For drinking and wound care

1. Martinez-Abreu J, et al. "Efficacy of OLEOZON compared to Alvogil in the treatment of alveolitis." Journal of Ozone Therapy. 2015. DOI: 10.7203/jo3t.1.1.2015.12162

2. Travagli V, et al. "Ozone and ozonated oils in skin diseases: a review." Mediators of Inflammation. 2010. PubMed

3. Bocci V. "Ozone: A New Medical Drug." Springer. 2005.
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4. Ugazio E, et al. "Ozonated oils as antimicrobial systems in topical applications." Ozone: Science & Engineering. 2020.

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