Ozone Therapy Machine Comparison

At A Glance:

1. To get the best results from ozone therapy, you need consistency, especially if you have chronic or complex health issues. This can get expensive to do in a spa or clinic. It’s best to get an ozone generator setup at home as this will save you money in the long run. Choosing the right ozone therapy machine is crucial for both safety and effectiveness. 
2. Key factors to consider while purchasing an ozone therapy machine include oxygen source compatibility, possible oxygen concentrations and precision, portability and ease of use, ozone-resistant materials, cold ozone production, availability of compatible accessories, customer service, portability, and certifications and warranties.
3. The best home consumer ozone therapy machine brands include SimplyO3, Promolife, and Longevity Resources. While not marketed for medical uses, SimplyO3 generators produce pure ozone-oxygen gas that is compatible for ozone therapy. These brands also sell professional or commercial models which can more precisely fine-tune ozone concentrations and function reliably with high volume of use. 
4. Practitioner and commercial-grade ozone generator brands also include Herrmann Apparatebau and European models like Zotzmann + Stahl. These companies, along with Longevity, also sell Extracorporeal Blood Oxygenation and Ozonation (EBOO) machines. 

To safely do ozone therapy, whether it’s at home or in a clinic, you need pure ozone-oxygen gas. This means it’s crucial to produce ozone from medical-grade 99.9% pure oxygen, not from an oxygen concentrator or room air. Also, because it’s unsafe to inhale ozone, the machines must have safety mechanisms compliant with the International Scientific Committee of Ozone Therapy guidelines [1]. 

This means it’s dangerous to repurpose an ozone generator for deodorizing a room or purifying water to use it for ozone therapy. These machines produce impure ozone from room air with other potentially corrosive and toxic gases. The only time it’s safe to use room air is when you’re ozonating water, for instance if you’re using ozone water to do laundry. 

In this article, we’ll compare different brands of ozone generators that can produce medical-grade ozone. 

For a more in-depth overview of technical specs and what to look for in a home ozone therapy machine, we recommend visiting this guide on choosing the right ozone generator.

Key Factors to Consider Before Buying

Before investing in an ozone therapy machine, it’s important to understand which features will affect safety, versatility, and long-term use. 

Oxygen Source Compatibility

Ozone for wellness applications should always be generated with high-purity oxygen, never from room air. This is not just a quality issue, it’s a safety issue. Using ambient air can result in the production of oxides of gases in the air, such as nitric oxide or pollutants. These contaminants can irritate tissues, making the resulting gas unsafe for medical use. 

When evaluating machines, make sure they’re compatible with oxygen tanks. Most vendors sell their own customized regulators that produce specific concentrations according to their charts. 

Some vendors also make it possible to produce ozone from low-flow oxygen concentrators, which produce 90–95% oxygen. This option can work for ozone saunas, ozonating water, and ozone insufflations, but not ozone IV. 

Some machines include quick-connect adapters or standard barbed fittings to attach regulators or oxygen tubing, while others may require additional accessories or adapters. If a unit doesn’t clearly state oxygen compatibility or only runs on ambient air, it’s not suitable for most ozone wellness uses.

A machine that integrates smoothly with your oxygen setup ensures consistent ozone output and avoids unnecessary frustration or additional purchases down the line.

Ozone Concentration Control

The ability to precisely control ozone concentration, measured in gamma (µg/mL), is a hallmark of a high-quality generator. Also, you need to be able to get into the range of ozone concentrations specific to the treatments you need. 

Most ozone generators achieve concentration control by adjusting:

• Oxygen flow rate: Lower flow generally increases ozone concentration; higher flow decreases it.
• Generator settings: Some machines offer an adjustable dial with multiple settings to fine-tune ozone output at each flow rate.
• Internal circuitry: Advanced units use built-in logic or feedback systems to maintain stable concentrations even if oxygen supply fluctuates.

The simplest and most affordable medical-grade ozone generators may only have one or two of these mechanisms. 

The manufacturer should provide a clear concentration chart that shows the expected ozone output (in µg/mL) across various oxygen flow rates and settings. If the manufacturer doesn’t provide this chart, it’s harder to ensure the accuracy of your setup.

When comparing models, look for:

• Wide concentration range (10–90 µg/mL or higher)
• Clear documentation of output at various settings

If you’re looking to apply ozone in various ways, such as insufflation, bagging, and ozonated water, you will benefit from a machine that can adapt easily between low and high concentrations.

Portability & Ease of Use

Some ozone generators are lightweight and come in compact, durable cases. These are ideal for users who need mobility and flexibility without sacrificing quality.

Key features that enhance portability and user experience include:

• Compact size: Smaller machines are easier to transport and require less counter space.
• Simple interface: A basic interface with clearly marked ports and settings reduces the learning curve.
• Plug-and-play design: Units that don’t require complex calibration or setup are more accessible to the average user.
• Integrated carrying case: Some higher-end models include medical-grade hard cases for safe transport.

On the other hand, larger clinical-grade machines, such as those used in EBOO or advanced ozone IV machines, may offer more power and versatility, but come with bulkier designs and steeper learning curves.

If ease of use and mobility matter to you, especially for home environments, mobile clinics, trade shows, or other kinds of travel, opt for a generator that balances medical-grade output with a user-friendly experience.

Materials and Build Quality

Medical ozone generators need to be made with ozone-resistant materials, such as:

• Medical-grade stainless steel or titanium for internal electrodes
• PTFE (Teflon), Kynar, or silicone for tubing and internal gas pathways
• Glass or ceramic to minimize chemical reactivity

These materials resist ozone corrosion and maintain the purity of the gas being produced. 

In contrast, cheaper devices that use plastics or rubber that may off-gas or break down with repeated use. These can introduce impurities into the ozone stream, and potentially into the body if used improperly.

Solid construction also extends to the machine's exterior. Rugged housings, reinforced connectors, and well-sealed ports prevent leaks and wear over time, which is especially important in clinical or repeated home use.

The use of ozone-inert materials internally is non-negotiable for safe, consistent output. This is one of the clearest separators between consumer-grade gimmicks and professional-grade equipment.

Certifications & Warranty

Reputable ozone therapy machines should be manufactured in facilities that adhere to quality standards such as:

• ISO 13485: Medical devices
• ISO 9001: General quality management

Some devices may also hold CE markings, indicating compliance with European health and safety standards. While not all ozone machines are marketed for medical use, machines made in certified facilities generally demonstrate a higher standard of design, testing, and reliability.

Even if a device is intended for non-medical purposes, certifications reassure buyers that materials are safe, components are traceable, and assembly follows consistent protocols. Lack of certification may suggest shortcuts in manufacturing or less rigorous testing procedures.

A good warranty, ideally one year or more, reflects the manufacturer’s confidence in their product. It also gives buyers peace of mind that if something fails prematurely, support and repairs are available. 

Many leading brands also offer lifetime customer service or guarantees on ozone-resistant parts like tubing or check valves.

Optional Accessories

The best ozone therapy machines will seamlessly connect to accessories with Luer locks or other connection mechanisms that prevent ozone leaks.

Ozone-resistant materials are a must across all accessories. 

Common optional add-ons include:

• Ozone bags for limb insufflation or localized ozone exposure.
• Glass or silicone syringes for ozone gas extraction and precise volume delivery.
• Water bubblers for making ozonated water or performing ear insufflation safely and efficiently.
• Oil bubblers for running ozone through the oil to create ozonides for inhalation.
• Ozone destruct units to safely neutralize excess ozone for clean room air during or after sessions.
• Ozone chambered bags for precise measurements of larger amounts of ozone.
• Catheters and funnels for topical or body cavity ozone delivery.
• Ozone-resistant IV bags and tubings for safe ozone IV therapies.

Choosing a generator with compatible, modular accessories can simplify your setup and reduce long-term costs.

Ozone Generator Brand Comparisons

SimplyO3 

SimplyO3 is one of the most recognized names in the ozone space, particularly for home users looking for reliable, contaminant-free ozone without the commercial price tag. 

While their devices are not marketed for clinical or medical use, their internal build quality, materials, and performance specs rival those of higher-end medical units. However, their user interfaces are extremely simple, making it accessible even to people with brain fog or disability.

Stratus 3.0

The Stratus is SimplyO3’s foundational model, ideal for users who want ease of use and precision with minimal adjustment.

It produces ozone concentrations ranging from 7 to 75 µg/mL using cold corona discharge, an efficient and heat-free method of generating ozone. Cold ozone production is crucial for the gas to be suitable for ozone therapy and to minimize ozone degradation between ozone generation and application. 

The components exposed to ozone include quartz glass, titanium, and silicone, all known for their ozone resistance.

Key features:

• CE electrical certified
• Lifetime rating of 10,000+ hours
• Worldwide voltage compatibility (110/220V)
• Single dial ozone control (dependent on oxygen flow rate)
• Small footprint and quiet operation
• 6-month money-back guarantee and lifetime warranty

This model pairs well with their customized oxygen regulators and connects seamlessly with accessories through Luer locks, making it accessible for both new and experienced users.

Cumulus

The Cumulus is SimplyO3’s professional-grade unit, offering enhanced flexibility and precision while still remaining user-friendly and cost-effective.

It includes all the features of the Stratus but adds more fine-tuned control through an adjustable dial combined with the oxygen flow rate, allowing for more precise ozone concentrations. 

This makes it a better fit for advanced applications or practitioners needing more detailed control, such as for IV applications.

Key features:

• Flow rate + dial setting adjustments for ozone concentration
• Custom-fitted concentration chart for accurate output
• Cold corona discharge with quartz glass, 316 stainless steel, and silicone internals
• CE-certified with Luer-lock ports for accessory compatibility
• Lifetime warranty and a 6-month money-back guarantee

The Cumulus’ precision control, rugged ozone-resistant build, and relatively compact size have made it popular in both home and professional environments, including among biohackers and alternative health communities.

Promolife

Promolife is a long-standing brand in the ozone therapy space, known for offering a range of machines tailored for both personal and professional use. 

From entry-level simplicity to clinical-grade performance, their lineup covers a wide spectrum of users. 

All Promolife devices are manufactured in the USA using ozone-compatible materials and are CE approved for safety and performance.

O3Arc Ozone Generator

The O3Arc is Promolife’s top-tier offering, engineered with clinical precision in mind. With support for several applications (from ozonated water to cupping and sauna therapy), this unit is clearly built for professional use. 

A standout feature is its foot pedal activation, allowing hands-free control and precise ozone delivery.

Key Features:

• Wide concentration range (up to 100 µg/mL)
• Cold corona discharge with 316 stainless steel fittings
• Optional foot pedal for on-demand ozone
• Includes a custom gamma chart
• Lifetime warranty on the cell and five-year warranty on controls

Drawbacks include:

• Higher price point (~$2,500)
• Larger footprint compared to more compact models
• Overkill for users only needing basic functionality
  

This is best for clinics, dentists, and serious home users who want a high-output, hands-free ozone solution with advanced capabilities.

O3Elite Mini Ozone Generator

For those just starting out or looking for a simple, reliable unit, the O3Elite Mini is Promolife’s most affordable and streamlined generator. 

It offers seven preset concentration settings up to 70 µg/mL using oxygen flow adjustment alone. The machine operates quietly using a single ceramic ozone cell that won't burn out. 

While it doesn’t have the range or precision of the O3Arc, it's a great fit for those focused on water ozonation, topical or basic insufflation uses.

Key Features:

• Simple, plug-and-play interface
• Ultra-quiet single ceramic cell
• Affordable (~$749)
• Garantía de por vida
• Wall-mountable

Drawbacks include:

• No foot pedal or dual-dial precision
• Not ideal for advanced or clinical applications
  

This is best for home users who want an easy-to-use, dependable unit without complex setup or advanced customization.

O3Elite Single Ozone Generator

The O3Elite Single strikes a balance between customization and simplicity. 

Like the Mini, it reaches up to 70 µg/mL, but unlike the Mini, it provides dozens more adjustable outputs based on flow rate and generator setting. 

It's compatible with most common ozone applications:

• Ozonating water
• Insufflations
• Ventosas de ozono
• Breathing ozone oil
• Full body ozone applications like bagging and sauna

Key Features:

• More concentration versatility than the Mini
• Customizable for a wide range of therapies
• Garantía de por vida

Drawbacks include:

• Slightly more expensive than the Mini (~$899)
• Lacks some of the clinical features found in the O3Arc
• Single ozone cell may not support parallel dual-port use
  

This is best for advanced home users or practitioners who need more output flexibility but don’t require all the features of a clinical-grade unit.

Longevity Resources

Longevity Resources’ line of ozone generators are built for precision, purity, and longevity. 

Designed with high-grade components and a proven track record in research labs worldwide, these machines are ideal for practitioners or institutions demanding the highest standards.

EXT50

Key Features:

• 1–65 µg/mL
• Cold corona with 100% quartz glass electrode and NEOS™ silent pulse system
• Compact (11″ × 6″ × 4.5″) and comes with a handy hard briefcase, making it a portable system
• Ultra-quiet
• Lightweight (~4 lbs)
• Universal voltage
• Purity testing with independent lab results
• Lifetime warranty on electrode, international compliance
  

This is best for professionals needing a stable, entry-to-mid-level unit with superior purity

EXT120 and EXT120‑T

Key Features:

• <1–120 µg/mL: the widest range available 
• Dual voltage, with only 0.4 amps of power required
• NEOS™ quartz and digital controls, optional built-in timer on “‑T” model
• Certifications: CSA/UL and CE (EXT120/‑T), including donor-verified purity & precision reports

This is best for users requiring broad range in outputs and frequent uses.

Quantum 5

Key Features:

• 1–120 µg/mL
• NEOS™ quartz electrode, which Longevity claims to be superior to ceramic, metal, or other materials
• Enhanced Pulse Injection Corona Technology that can run all day long, making it suitable for commercial uses
• on‑demand syringe port
• built‑in destruct unit
• Extras: LED timer, foot pedal remote control, digital-grade precision with syringe accuracy

This is best for research labs or clinics needing hands‑free dosing, high precision, and on-demand delivery.

Quantum 3

Key Features:

• 1–120 µg/mL
• NEOS™ quartz electrode
• Two independent ozone ports with syringe control, so the Quantum 3 functions like having two ozone generators in one  

This is best for practices requiring simultaneous use or parallel protocols, such as in a busy medical practice.

SimplyO3 vs. Promolife vs. Longevity 

Choosing an ozone generator often comes down to balancing precision, build quality, and value. 

Below is a side-by-side comparison of the three most popular ozone generator brands to help clarify where each one shines:

SimplyO3 offers excellent value, strong ozone purity, and portability, though with fewer advanced controls.

Promolife provides a wide range of options from beginner-friendly to clinical-grade with customizable outputs.

Longevity is geared toward professionals and researchers who demand the highest concentration, precision, and purity.

Each brand has a niche, and understanding your application needs and your comfort level with setup and calibration will help guide your decision.

Herrmann Apparatebau

Herrmann Apparatebau offers a range of high-end ozone therapy machines engineered in Germany, primarily for medical and clinical use. 

Their most prominent models include the Hyper Medozon Comfort and the Medozon Compact. These units are CE-certified medical devices, built to support a broad range of normobaric and hyperbaric ozone applications.

Key Features:

• 2–80 µg/mL, at 1.0 L/min
• Touchscreen interface
• Vacuum function
• Closed system design: Supports contamination-free ozone delivery and compatibility with medical carts (e.g., WEIKO Ozone Cart).
  

Application modes include:

• Large autohemotherapy (Hyper Medozon Comfort only, with normobaric and hyperbaric options) and with multi-passes
• Small autohemotherapy
• Intestinal insufflation
• Water ozonation
• Syringe fills
  

Both models also support Aquazon integration and include a transport case option for clinics requiring mobility. 

For advanced practitioners seeking precise ozone concentration management, Herrmann’s machines are among the most sophisticated on the market.

Zotzmann + Stahl

Zotzmann + Stahl, a German-based manufacturer, offers two robust medical-grade ozone therapy devices: the OZON 2000 and the OZON N. 

OZON 2000

The OZON 2000 is a full-featured medical ozone generator that integrates multiple layers of protection and is compatible with medical-grade oxygen.

Key Features:

• Dual Voltage: 100–240 V AC (worldwide compatible)
• Flow Control: Special pressure reducer with flow meter for fine-tuned ozone generation
• Safety Mechanisms:
  
  • Time-controlled pressure relief
  • Air-Bloc safety system
• Discharge Nozzles: LUER / LUER LOK connections
• Device Weight: Approx. 14 kg
• Fuse Protection: 2 x 0.630 A (230 V) or 2 x 1.25 A (120 V), slow-burn fuses

This unit is engineered for clinicians who require a reliable and high-output device capable of handling demanding protocols with robust fail-safes in place.

OZON N

A more compact alternative, the OZON N retains many of the core features of the OZON 2000 but is tailored for practices that require portability without compromising accuracy.

Key Features:

• Dual voltage: 100–240 V AC (universal input)
• Lower Output: Max 80 VA, making it more energy efficient
• Flow Control: Same fine adjustment regulator with flow meter
• Discharge Nozzles: LUER connections (positive/negative)
• Weight: Approx. 8.2 kg
• Fuse Protection: Same slow-burn safety fuses
  

Both units are CE compliant and utilize ozone-resistant materials. 

Although not marketed with flashy features, they have a strong reputation among European practitioners for consistency, durability, and well-calibrated dosing control.

Chinese Ozone Generators (Generic Amazon Units)

A quick search for “ozone generator” on Amazon yields dozens of compact, low-cost devices, many of which are manufactured in China and sold under rotating brand names. These are ozone odor removers or fish tank cleaners. 

While the appeal of a sub-$200 ozone generator is understandable, these devices are typically not recommended for high-purity or therapeutic applications.

Common Features:

• Low Price Point: Often priced between $30–$200
• Air-fed or ambient air ozone production (not compatible with oxygen tanks)
• Unspecified or unverified ozone output levels
• Plastic housings and unknown internal materials that are susceptible to ozone degradation
• No certifications (CE, FDA, UL, etc.)
• Single-port output with limited control

By using ambient air instead of oxygen, the resulting gas from these devices may contain oxidized nitrogen byproducts (NOx). As a result, the ozone output may be dangerous for most therapeutic or food-grade uses.

Many of these units do not come with reliable concentration charts, technical support, or replacement parts, making long-term use difficult or unsafe.

These generators may be acceptable for basic household sanitation tasks (deodorizing rooms), but they are not suitable for precision applications.

Ozone Therapy Machines for Professional Use

For clinics, wellness centers, or medical practitioners offering ozone therapy, machine selection directly affects:

• Consistency
• Seguridad
• Therapeutic potential

Professional-grade ozone generators are engineered for high-frequency use, advanced treatment protocols, and integration with other medical systems such as:

• EBOO (extracorporeal blood oxygenation and ozonation)
• Saunas de ozono
• Ozonoterapia intravenosa

What Sets Professional Machines Apart

Internal components are typically made of ozone-inert materials and feature built-in sensors or microprocessors to auto-adjust flow and concentration levels with high accuracy, ideal for complex dosing protocols.

Professional machines may reach up to 100 µg/mL (gamma) or more, with tight control over incremental adjustments.

Auto shut-off timers, pressure relief valves, and over-ozone alarms are common, protecting both operators and patients.

Most professional units are ISCO3 compliant and may carry CE, ISO, or FDA certifications (where applicable) and are often approved for use in regulated clinical environments.

Popular brands in clinical settings include:

• Herrmann Apparatebau
• Zotzmann + Stahl OZON 2000 and OZON N, often used in hospital and integrative therapy settings worldwide
• Longevity Resources Quantum series and EXT120-T, suitable for both IV-compatible protocols and EBOO configurations
• Promolife O3Arc model
• Simply O3 Cumulus
  

Considerations for clinical buyers include:

• Support and Training: Choose manufacturers that provide post-sale education, calibration guidance, and customer service tailored to medical use.
• Legal Compliance: Ensure the generator complies with country-specific medical device regulations, especially if it will be used intravenously or with patient-contact therapies.
• Repair coverage: Extended warranty and accessible repair options.

Extracorporeal blood oxygenation and ozonation (EBOO) machines

During EBOO, or recirculatory hemoperfusion, a large volume of blood is withdrawn from the body, exposed to medical-grade ozone and oxygen, then returned via a closed-loop system in another vein [2]. Although EBOO is not dialysis, EBOO machines subject the blood to a filtering step. 

EBOO, therefore, requires specialized equipment more sophisticated than ozone generators. They need to have pumps, more tubings, and filtration cartridges.

Some models even include inline UV, laser, or infrared therapy add-ons to complement the ozone treatment.

Key distinguishing features include:

• Integrated peristaltic pumps to regulate blood flow and prevent clotting or turbulence
• Real-time ozone dosing to maintain consistency over longer treatment sessions
• Closed-loop safety protocols like leak detection or automatic shutdowns to protect both patient and operator
• CE or ISO certification

EBOO manufacturers include:

• Herrmann Medozon Comfort
• Zotzmann + Stahl OZON 2000
• Longevity Resources Quantum 5

Even the best EBOO machine won’t function as intended without a complete setup. Typical systems also require:

• EBOO bloodline kits (sterile and disposable)
• Heparinization protocols (to prevent clotting)
• Dialyzers or filtration columns (optional but sometimes included)
• Medical-grade oxygen supply
• Temperature and pressure monitors (included in advanced models)
  

These systems are primarily used in:

• Licensed integrative medical clinics
• Regenerative medicine practices
• High-end wellness centers

Due to their cost and complexity, EBOO machines are rarely purchased by home users and are not intended for DIY use.

Real User Experiences & Reddit Reviews

While technical specs and certifications tell one story, real-world usage across forums, Reddit threads, and independent reviews often paints a more nuanced picture of how ozone generators perform in practice. 

SimplyO3

SimplyO3 is consistently praised for its transparency, customer service, and ease of use. On Reddit’s r/Biohackers and similar wellness communities, users often mention the Stratus and Cumulus models as ideal entry-level or intermediate options. 

Many appreciate the clean design, reliable concentration charts, and accessible learning curve. 

One user wrote, “Simply O3 has an ozone generator that comes with everything you’ll need to do various forms of ozone therapy, including a special regulator for an oxygen bottle.” Others in the reviews on the product’s webpage echoed this sentiment, highlighting the lifetime warranty and no-nonsense customer support as deciding factors.

Promolife

Promolife’s O3Elite line has developed a strong following, especially among users looking for a broader range of settings and customization options. Reviewers often point out the durability of the ceramic ozone cells and the foot pedal operation on their O3Arc model. 

Some users applaud the brand, saying ““I love Promolife! They are a great company with high quality products.” Meanwhile, others suggest that the higher price point is offset by clinical reliability and “truly contaminant-free output.” 

However, a few reviewers on the product’s website noted the learning curve with multiple concentration settings can be intimidating for beginners.

Longevity Resources

Longevity’s EXT and Quantum series are most often discussed in professional settings or by advanced users seeking integration with EBOO protocols. 

Users reviewing the product cite their industrial-level build quality, quiet operation, and strong regulatory credentials. 

Generic Amazon Units

Reviews of Chinese-made ozone generators found on Amazon are, predictably, a mixed bag. 

Some users report acceptable results for very light applications like water ozonation, but recurring complaints include inconsistent output, metal corrosion, noisy fans, and zero customer support. 

An amazon user summarized the risk aptly: “If it doesn't say what it's made from or include an output chart, assume it's cutting corners.”

Choose the Right Fit for Your Use

With so many ozone therapy machines on the market it’s easy to get overwhelmed. But narrowing down the right choice often comes down to three things:

• Intended use
• Level of precision needed
• Budget

For most users seeking reliability, clean materials, and ease of use, SimplyO3's Stratus and Cumulus models strike a well-balanced middle ground. 

If you need expanded customization, multiple outputs, or plan to offer ozone as part of a wellness or naturopathic practice, SimplyO3’s Cumulus and Promolife offer more fine-tuning and modular features. 

For clinical environments or integrative therapies like EBOO, Longevity, Herrmann, and Zotzmann + Stahl deliver professional-grade options.

A reliable machine isn’t just about features, it’s about consistency, safety, and trust in what you're producing.

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Referencias

1 Konrad, H. (2014, July 11) Guidelines and Recommendations for Medical Professionals Planning to Acquire a Medical Ozone Generator

2 Di Paolo, N., Gaggiotti, E. and Galli, F. (2005) Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Rep. 10, 121–130